SidaSubSaharaV1, Main, Exploration, bibRecord, 000A58

Cervicovaginal Inflammation Facilitates Acquisition of Less Infectious HIV Variants.

Identifieur interne : 000A58 ( Main/Exploration ); précédent : 000A57; suivant : 000A59

Cervicovaginal Inflammation Facilitates Acquisition of Less Infectious HIV Variants.

Auteurs : Philippe Selhorst ; Lindi Masson ; Sherazaan D. Ismail ; Natasha Samsunder ; Nigel Garrett ; Leila E. Mansoor ; Quarraisha Abdool Karim ; Salim S. Abdool Karim ; Jo-Ann S. Passmore ; Carolyn Williamson

Source :

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America [ 1537-6591 ] ; 2017.

RBID : pubmed:27694480

Abstract

We evaluated whether genital inflammation affects the selection of the transmitted virus. Among South African women, we found that preinfection genital inflammation facilitates transmission of less infectious human immunodeficiency virus, but highly infectious viruses are able to establish infection regardless of inflammation status. This suggests that viral phenotype can influence transmission risk.

DOI: 10.1093/cid/ciw663
PubMed: 27694480

Affiliations:

Le document en format XML

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<front><div type="abstract" xml:lang="en">We evaluated whether genital inflammation affects the selection of the transmitted virus. Among South African women, we found that preinfection genital inflammation facilitates transmission of less infectious human immunodeficiency virus, but highly infectious viruses are able to establish infection regardless of inflammation status. This suggests that viral phenotype can influence transmission risk.</div>
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<tree><noCountry><name sortKey="Abdool Karim, Quarraisha" sort="Abdool Karim, Quarraisha" uniqKey="Abdool Karim Q" first="Quarraisha" last="Abdool Karim">Quarraisha Abdool Karim</name>
<name sortKey="Abdool Karim, Salim S" sort="Abdool Karim, Salim S" uniqKey="Abdool Karim S" first="Salim S" last="Abdool Karim">Salim S. Abdool Karim</name>
<name sortKey="Garrett, Nigel" sort="Garrett, Nigel" uniqKey="Garrett N" first="Nigel" last="Garrett">Nigel Garrett</name>
<name sortKey="Ismail, Sherazaan D" sort="Ismail, Sherazaan D" uniqKey="Ismail S" first="Sherazaan D" last="Ismail">Sherazaan D. Ismail</name>
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<name sortKey="Samsunder, Natasha" sort="Samsunder, Natasha" uniqKey="Samsunder N" first="Natasha" last="Samsunder">Natasha Samsunder</name>
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Cervicovaginal Inflammation Facilitates Acquisition of Less Infectious HIV Variants.

Cervicovaginal Inflammation Facilitates Acquisition of Less Infectious HIV Variants.

Source :

Abstract

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